Motilin receptor in GtoPdb v.2023.1

Motilin receptors (provisional nomenclature) are activated by motilin, a 22 amino-acid peptide derived from precursor (MLN, P12872), which may also generate motilin-associated peptide. There significant species differences in the structure of motilin and its receptor, functions motilin. In humans large mammals such as dog, activation these released endocrine cells duodenal mucosa during fasting, induces propulsive phase III movements. This activity is associated with promoting hunger humans. other drugs non-peptide compounds activate receptor more long-lasting ability to increase cholinergic within upper gut, promote gastrointestinal motility; this suggested be responsible for prokinetic effects certain macrolide antibacterials (often called motilides; e.g. erythromycin, azithromycin), although many molecules evidence sparse. Relatively high doses induce vomiting humans, nausea.